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KMID : 0377619770330010017
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Korean Jungang Medical Journal
1977 Volume.33 No. 1 p.17 ~ p.27
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Experimental Brain and Spinal Cord Compression - Pathophysiology and Treatment -
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Abstract
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The cerebral compression and edema were successfully produced by the expansion of the stalk of laminaria in the right epidural space of the rabbits. By weighing the wet and dry brain tissues, and by calculating the percentage of water content and that of swelling, with the rate of per cent water content to that of control group, the studies of the occurrence and changes of experimental brain edema have been observed.
In the normal rabbits, the average per cent water content of cerebral gray and white matters were 79.9±0.7% and 73.0±1.0%, respectively.
The percentage of cerebral gray and white matters in the compression site showed higher values than those in control group. As compared . with normal group, the rate of per cent water content of cerebral gray matter at the site of compression showed gradual increasing tendency as time elapsed by 24 hours, while that of white matter demonstrated rapid increased of it by 6 hours and decreased gradually thereafter. And it appeared that the value of the cerebral white matter showed higher than that of gray matter´ throughout the period of 24 hour´s compression. Cerebral edema induced by laminaria compression was more evident and severe in the white matter than in the gray, which was more striking at the early stage of cerebral compression.
Experimental spinal cord compression was successfully produced in the rabbit by the expansion of the stalks of "laminaria", a sea weed, which was placed in the spinal epidural space at the level of fifth lumbar vertebrae. The experimental spinal cord compression and subsequent edema at the site of compression were studied at interval of 6, 1 land 24 hour´s compression by measuring wet weight and dry weight, and by calculating per cent water content, swelling percent and change of water content to that in control group.
In the normal rabbit, the average water content of the spinal cord was 63. 3±0. 9,a. The percentage of water and swelling of the cord tissues in experimental group were higher than those in the control during the period of 24 hour´s compression, and that at the site of compression they showed a tendency of rapid increase in value at an early stage.
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